Soligenix’s HyBryte Shows Superior Efficacy and Safety Over Valchlor in CTCL Treatment Study

Soligenix announced the publication of positive results from its comparability study evaluating HyBryte versus Valchlor for the treatment of cutaneous T-cell lymphoma in Oncology and Therapy. The study revealed that after 12 weeks, 60% of HyBryte-treated patients achieved treatment success compared to 20% for Valchlor, with greater average improvement and no treatment-related adverse events reported for HyBryte. In contrast, Valchlor patients experienced multiple adverse reactions during the study period.

The findings support HyBryte’s potential as a well-tolerated therapy for early-stage CTCL, a rare form of non-Hodgkin lymphoma that affects the skin. The company’s Specialized BioTherapeutics business segment is developing and moving toward potential commercialization of HyBryte as a novel photodynamic therapy utilizing safe visible light for CTCL treatment. With successful completion of the second Phase 3 study, regulatory approvals will be sought to support potential commercialization worldwide.

Development programs in this business segment also include expansion of synthetic hypericin into psoriasis, as well as the company’s first-in-class innate defense regulator technology for inflammatory diseases. The company’s Public Health Solutions business segment includes development programs for vaccine candidates targeting various infectious diseases, supported with government grant and contract funding from agencies including the National Institute of Allergy and Infectious Diseases and the Biomedical Advanced Research and Development Authority.

The full study results are available in the publication, and additional information about the company’s research can be found through their corporate communications. The latest news and updates relating to Soligenix are available through various financial information platforms that track pharmaceutical developments.

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